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Journal Articles and Reviews


  • A. Paschold, M.  Schäffler, X. Miao, L. Gardon, S. Krüger, H.  Heise, M.I.S. Röhr, M. Ott, B. Strodel, W.H. Binder (2024). Photocontrolled Reversible Amyloid Fibril Formation of Parathyroid Hormone-Derived Peptides. Bioconjugate Chem. 2024, in press.
  • K. Herr, M.V. Höfler, H. Heise, F. Aussenac, F. Kornemann, D. Rosenberger, M. Brodrecht, M. de Oliveira, G. Buntkowsky, T. Gutmann, T. (2024). Biradicals based on PROXYL containing building blocks for efficient dynamic nuclear polarization in biotolerant media. J. Magn. Reson. Open, 2024, 20, 100152.
  • L. Gardon, N. Becker, L. Gremer, H. Heise, Structural Impact of N-terminal Pyroglutamate in an Amyloid-β(3-42) Fibril Probed by Solid-State NMR Spectroscopy. Chem. Eur. J. 2024, 30, e202303007.


  • L. Gardon, N. Becker, N. Rähse, C. Hölbling, A. Apostolidis, C. M. Schulz, K. Bochinsky, L. Gremer, H. Heise, N.-A. Lakomek, Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques, Front. Mol. Biosci. 2023, 10.
  • N. Becker, B. Frieg, L. Gremer, T. Kupreichyk, L. Gardon, P. Freiburg, P. Neudecker, D. Willbold, H. Gohlke, H. Heise, Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1–42) Amyloid Fibrils. J. Am. Chem. Soc. 2023, 145, 2161.


  • L. Rösler, M. V. Höfler, H. Breitzke, T. Wissel, K. Herr, H. Heise, T. Gutmann, G. Buntkowsky,  Dirhodium complex immobilization on modified cellulose for highly selective heterogeneous cyclopropanation reactions. Cellulose 2022, 29, 6283.


  • A. Cukkemane, N. Becker, M. Zielinski, B. Frieg, N.-A. Lakomek, H. Heise, G. F. Schröder, D. Willbold, O. H. Weiergräber, Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses. Translational Psychiatry 2021, 11, 639.

  • D. Willbold, B. Strodel, G. F. Schröder, W. Hoyer, H Heise, Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids, Chem. Rev. 2021, 121:8285-8307.

  • K. Herr, M. Fleckenstein, M. Brodrecht, M. V. Höfler, H. Heise, F. Aussenac, T. Gutmann, M. Reggelin, G. Buntkowsky, A Novel Strategy for Site Selective Spin-Labeling to Investigate Bioactive Entities by DNP and EPR Spectroscopy, Sci. Rep. 2021, 11:13714.

  • A. König, N. Rösener, L. Gremer, M. Tusche, D. Flender, E. Reinartz, W. Hoyer, P. Neudecker, D. Willbold, H. Heise, Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy, J. Biol. Chem. 2021, 296, 100499.


  • B. Frieg, L. Gremer, H. Heise, D. Willbold, H. Gohlke,  Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1–42). Chem.Commun. 2020, 56, 7589-7592.
  • H. Park, B. Uluca-Yazgi, S. Heumann, R. Schlögl, J. Granwehr, H. Heise, P. P. M. Schleker, Heteronuclear cross-relaxation effect modulated by the dynamics of N-functional groups in the solid state under 15N DP-MAS DNP, J. Magn. Reson. 2020, 312, 106688.


  • L. Siemons, B. Uluca-Yazgi, R. B. Pritchard, S. McCarthy, H. Heise, D. F. Hansen,  Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift, Chem. Commun. 2019, 55, 14107-14110.
  • H. Eraña, J. M. Charco, M. A. Di Bari, C. M. Díaz-Domínguez, R. López-Moreno, E. Vidal, E. González-Miranda, M. A. Pérez-Castro, S. García-Martínez, S. Bravo, N. Fernández-Borges, M. Geijo, C. D’Agostino, J. Garrido, J. Bian, A. König, B. Uluca-Yazgi, R. Sabate, V. Khaychuk, I. Vanni, G. C. Telling, H. Heise, R. Nonno, J. R. Requena, J. Castilla, Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies, PLOS Pathogens 2019, 15, e1008117.
  • A. König, D. Schölzel, B. Uluca, T. Viennet, Ü. Akbey, H. Heise, Hyperpolarized MAS NMR of unfolded and misfolded proteins, Solid State NMR, 2019, 98, 1-11.


  • N.S. Rösener, L. Gremer, E. Reinartz, A. König, O. Brener, H. Heise, W. Hoyer, P. Neudecker, D. Willbold, A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein, J. Biol. Chem.  2018, 293, 15748–15764.
  • F. Hasecke, T. Miti, C. Perez, J. Barton, D. Schölzel, L. Gremer, C.S.R. Grüning, G. Matthews, G. Meisl, T.P.J. Knowles, D. Willbold, P. Neudecker, H. Heise, G. Ullah, W. Hoyer, M. Muschol, Origin of metastable oligomers and their effects on amyloid fibril self- assembly, Chemical Science, 2018, 9, 5937-5948.
  • T. Viennet, M. M. Wördehoff, B. Uluca, C. Poojari, H. Shaykhalishahi, D. Willbold, B. Strodel, H. Heise, A. K. Buell, W. Hoyer & M. Etzkorn, Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation. Communciations Biology, 2018,  1, 44.
  • B. Uluca, T. Viennet, D. Petrović, H. Shaykhalishahi, F. Weirich, A. Gönülalan, B. Strodel, M. Etzkorn, W. Hoyer, and H. Heise. DNP-Enhanced solid-state NMR at Cryogenic Temperatures: a Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States. Biophys. J. 2018, 114, 1614-1623.
  • Y. Ohhashi, Y. Yamaguchi, H. Kurahashi, Y. O. Kamatari, S. Sugiyama, B. Uluca, T. Piechatzek, Y. Komi, T. Shida, H. Müller, S. Hanashima, H. Heise, K. Kuwata, and M. Tanaka, Molecular basis for diversification of yeast prion strain conformation. PNAS, 2018, 115, 2389-2394.
  • A. Kulawik, H. Heise, C. Zafiu, D. Willbold, and O. Bannach, Advancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases. FEBS Letters 2018, 592, 516-534. 
  • C. Beumer, A. König, D. Schölzel, B. Uluca, F. Weirich, H. Heise, Methods for complex systems - Isotopically enriched systems, in "Modern Methods in Solid-State NMR: A Practitioners’ Guide" (P. Hodginson, Ed.), Royal Soc. Chem. 2018, 289-321.


  • L. Gremer, D. Schölzel, C. Schenk, E. Reinartz, J. Labahn, R. Ravelli, M. Tusche, C. Lopez-Iglesias, W. Hoyer, H. Heise, D. Willbold, G. Schröder, Fibril structure of amyloid-ß(1-42) by cryo-electron microscopy, Science, 2017, 358, 116-119.


  • T. Viennet, A. Viegas, A. Kuepper, S. Arens, V. Gelev, O. Petrov, T. N. Grossmann, H. Heise, M. Etzkorn, Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew. Chem. Int. Ed. Engl. 2016, 55, 10746-10750.
  • F. Weirich, L. Gremer, E.A: Mirecka, S. Schiefer, W. Hoyer, H. Heise. Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment is Part of the beta-sheet Core, PLoS ONE, 2016, 11, e0161243.


  • W. Hoyer, H. Shaykhalishahi, S. Ayalur-Karunakaran, H. Heise, Structural characterization of alpha-Synuclein amyloids, In The Prion Phenomena in Neurodegenerative Diseases: New Frontiers in Neuroscience (G. Giachin and G. Legname, Eds.), 2015, pp 111-128, Nova Biomedical.


  • H. Müller, O. Brener, O. Andreoletti, T. Piechatzek, D Willbold, G. Legname, H. Heise, Progress towards structural understanding of infectious sheep PrP-amyloid, Prion, 2014, 8, 344-358.
  • S.-C. Zhang, L. Gremer, H. Heise, P. Janning, A. Shymanets, I.C. Cirstea, E. Krause, B. Nürnberg, M.R. Ahmadian,. Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1. PLoS ONE, 2014, 9, e102425.



  • R. Schneider, M. C.  Schumacher, H. Mueller, D. Nand, V. Klaukien, H. Heise, D. Riedel, G. Wolf, E. Behrmann, S. Raunser, R. Seidel, M. Engelhard, M. Baldus, Structural Characterization of Polyglutamine Fibrils by Solid-State NMR Spectroscopy. J. Mol. Biol. 2011, 412, 121-136.


  • A. Kumar, H. Heise, M.J.J. Blommers, P. Krastel, E. Schmitt, F. Petersen, E.M. Mandelkow, T. Carlomagno, C. Griesinger, M. Baldus,Interaction of Epothilone B (Patupilone) with Microtubules, As Detected by Two-Dimensional Solid-State NMR Spectroscopy, Angew. Chem. Int. Ed. 2010, 49, 7504-7507.


  • D.P. Karpinar, M.B.G. Balija, S. Kügler, F. Opazo, N. Rezaei-Ghaleh, N. Bender, H.-Y. Kim, G. Taschenberger, B.H. Falkenburger, H. Heise, A. Kumar, D. Riedel, L. Fichtner, A. Voigt, G.H. Braus, K. Giller, S. Becker, A. Herzig, M. Baldus, H. Jäckle, S. Eimer, J.B. Schulz, C. Griesinger, M. Zweckstetter, Pre-fibrillar alpha-Synuclein Variants with Impaired beta-Structure Increase Neurotoxicity in Parkinson`s Disease Models, EMBO J.,2009, 28, 3256 - 3268.


  • H. Heise, Solid-State NMR Spectroscopy of Amyloid Proteins, ChemBioChem, 2008, 9, 179-189.
  • C. Gardiennet, A. Loquet, M. Etzkorn, H. Heise, M. Baldus, A. Böckmann, Structural constraints for the Crh protein from solid-state NMR experiments, J. Biomol. NMR, 2008, 40, 239-250.
  • H. Heise, M.S. Celej, S. Becker, D. Riedel, A. Pelah, A. Kumar, T.M. Jovin, M. Baldus, Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein, J. Mol. Biol. 2008, 380, 444-450.


  • H.-Y. Kim, H. Heise, C.O. Fernandez, M. Baldus, M. Zweckstetter, Correlation of Amyloid Fibril beta-Structure with the Unfolded State of alpha-Synuclein, ChemBioChem, 2007, 8, 1671-1674.



  • O. Benedi Borobia, P. Guionneau, H. Heise, F.H. Köhler, L. Ducasse, J. Vidal-Gancedo, J. Veciana, S. Golhen, L. Ouahab, J.-P. Sutter: Discrepancy Between the Spin Distribution and the Magnetic Ground State for a Tri-Aminoxyl Substituted Triphenylphosphine Oxide Derivative, Chem. Eur. J. 2005, 11, 128-139.
  • H. Heise, K. Seidel, M. Etzkorn, S. Becker, M. Baldus: 3D MAS Solid State NMR Spectroscopy for Resonance Assignment and Structure Elucidation of Proteins. Novel Pulse Schemes and Sensitivity Considerations, J. Magn. Reson. 2005, 173, 64-74.
  • H. Heise, S. Luca, B.L. deGroot, H. Grubmüller, M. Baldus: Probing Conformational Distributions by High-Resolution Solid-State NMR and MD Simulations: Application to Neurotensin, Biophys. J. 2005, 89, 2113-2120.
  • S. Luca, H. Heise, A. Lange, M. Baldus: Investigation of Ligand-receptor Interactions by High-Resolution Solid-State NMR, Arch. Pharm. Chem. Life Sci., 2005, 338, 217-228.
  • K. Seidel, M. Etzkorn, H. Heise, S. Becker, M. Baldus: High-resolution solid-state NMR studies on uniformly [13C,15N] labeled Ubiquitin, ChemBioChem, 2005, 6, 1638-1647.
  • O.C. Andronesi, S. Becker, K. Seidel, H. Heise, H. S. Young, M. Baldus, Determination of Membrane Protein Structure and Dynamics by Magic-Angle-Spinning Solid-State NMR, J. Am. Chem. Soc. 2005, 127, 12965 - 12974.
  • H. Heise, W. Hoyer, S. Becker, O.C. Andronesi, D. Riedel, M. Baldus, Molecular Level Secondary Structure, Polymorphism and Dynamics of Full-length alpha-Synuclein Fibrils Studied by Solid-State NMR, PNAS, 2005, 102,15871-15876.


  • D. C. Sporer, H. Heise, K.Wurst, D. Ruiz-Molina, H. Kopacka, P. Jaitner, F. H. Köhler, J.J. Novoa, J. Veciana: Magneto-Structural Characterization of Metallocene-Bridged Nitronyl Nitroxide Diradicals by X-Ray, Magnetic Measurements, Solid-state NMR Spectroscopy, and Ab Initio Calculations, Chem. Eur. J. 2004, 10, 1355-1365.
  • C. Rancurel, H. Heise, F.H. Köhler, U. Schatzschneider, E. Rentschler, J. Vidal-Gancedo, J. Veciana, J.-P. Sutter: Spin Transfer and Magnetic Interaction via Phosphorus in Nitronyl Nitroxide Radical-Substituted Triphenylphosphine Derivatives, J. Phys. Chem. A, 2004, 108, 5903 -5914.
  • V.K. Koltover, J.W. Logan, H. Heise,V.P. Bubnov, Y.I. Estrin, V.P. Lodygina, A. Pines: Diamagneitc Clusters of Paramagnetic Endometallofullerenes: A Solid-State MAS NMR Study, J. Phys. Chem. B, 2004, 108, 12450 -12455.
  • R. Ziessel, C. Stroh, H. Heise, F.H. Köhler, P. Turek, N. Claiser, M. Souhassou, C. Lecomte: Strong Exchange Interactions between Two Radicals Attached to Nonaromatic Spacers Deduced from Magnetic, EPR, NMR, and Electron Density Measurements, J. Am. Chem. Soc. 2004, 126, 12604-12613.
  • K. Seidel, A. Lange, S. Becker, C.E. Hughes, H. Heise, M. Baldus: Protein Solid-State NMR Resonance Assignments from (13C,13C) Correlation Spectroscopy, Phys. Chem. Chem. Phys. 2004, 6, 5090-5093.


  • A. Böckmann, A. Lange, A. Galinier, S. Luca, N. Giraud, M. Juy, H. Heise, R. Montserret, F. Penin, M. Baldus: Solid State NMR Sequential Resonance Assignments and Conformational Analysis, of the 2x10.4 kDa Dimeric Form of the Bacillus Subtilis Protein Crh, J. Biomol. NMR, 2003, 27, 323-339.
  • S. Luca, H. Heise, M. Baldus: High-Resolution Solid State NMR applied to Polypeptides and Membrane Proteins, Acc. Chem. Res. 2003, 36, 858-865.


  • H. Heise, D. Sakellariou, C. A. Meriles, A. Moule, A. Pines: 2-Dimensional High-resolution NMR Spectra in Matched Bo and B1 Field Gradients, J. Magn. Reson. 2002, 156, 146-151.
  • H. Heise, F. H. Köhler, M. Herker, W. Hiller: Solid-state NMR investigations on paramagnetic metallocenium salts: Probing intra- and intermolecular spin density distribution, J. Am. Chem. Soc. 2002, 124, 10823-10832.
  • S. Wi, H. Heise, A. Pines: Reintroducing Anisotropic Interactions in Magic-Angle-Spinning NMR of Half-Integer Quadrupolar Nuclei: 3D MQMAS, J. Am. Chem. Soc. 2002, 124, 10652-10653.



  • G. W. Rabe, H. Heise, L. M. Liable-Sands, I. A. Guzei, A. L. Rheingold: Synthesis and X-ray Crystal structure Determination of two monomeric Alkali Metal Phosphide Derivatives: [MPH(tBu3Mes)](18-crown-6) (M=K, Rb). J. Chem.Soc., Dalton Trans, 2000, 12, 1863-1866.


  • H. Heise, F. H. Köhler, E. Brouwer, R. K. Harris, S. Steuernagel: 59Co second-order quadrupolar effects in the 13C CP/MAS-NMR spectra of the cobaltocenium salts [Cp*2Co]+[PF6]- and [Cp*CpCo]+[PF6]-. Magn. Reson. Chem. 1999, 37, 573-578.
  • L. Djakovitch, H. Heise, K. Köhler: Heck reactions between aryl halides and olefins catalysed by Pd-complexes entrapped into zeolites NaY. J. Organomet. Chem. 1999, 584, 16-26.
  • H. Heise, F. H. Köhler, J. Veciana, F. Mota, J. J. Novoa: Determination of the Spin Distribution in Nitronylnitroxides by Solid-State-NMR Spectroscopy. J. Am. Chem. Soc. 1999, 121, 9659-9667.


  • G. W. Rabe, S. Kheradmandan, H. Heise, I. A. Guzei, L. M. Liable-Sands, A. L. Rheingold: Influence of Donor Solvents on the Molecular Structure of KP(tBu)Ph. Main Group Chem. 1998, 2, 221 - 228.
  • G. W. Rabe, H. Heise, G. P. A. Yap, L. M. Liable-Sands, I. A. Guzei, A. L. Rheingold: Molecular Structures of the Heavier Alkali Metal Salts of Supermesitylphosphane: A Systematic Investigation. Inorg. Chem. 1998, 37, 4235 - 4245.



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